Effect of 5-HT1A Receptor Partial Agonists of the Azapirone Class as an Add-On Therapy on Psychopathology and Cognition in Schizophrenia: A Systematic Review and Meta-Analysis.

Int J Neuropsychopharmacol · 2023 · PMC10109009 · PMID 36721972

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did not reach statistical significanceno p-value reported

Results Random-effects model meta-analyses revealed that add-on therapy with buspirone or tandospirone had a significant beneficial effect on overall psychotic symptoms (SMD = –1.13, 95% CI = –1.98 to –0.27) and positive symptoms (SMD = –0.72, 95% CI =–1.31 to –0.12), while the effect on negative symptoms did not reach statistical significance (SMD = –0.93, 95% CI = –1.90 to 0.04).

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