Promise and Peril of Pretomanid-Rifamycin Regimens for Drug-susceptible Tuberculosis.

In the APT trial, the pretomanid–rifabutin regimen was associated with a significantly higher hazard of culture conversion with an adjusted hazard ratio of 1.89 (95% confidence interval [CI], 1.24–2.87; P = 0.003) as compared with the control regimen, whereas the pretomanid–rifampin regimen showed a trend toward a higher hazard of culture conversion with an adjusted hazard ratio of 1.41 (95% CI, 0.93–2.12; P = 0.10), both in liquid media.

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In contrast, the pretomanid–rifampin combination likely decreased pretomanid exposures such that its effect on time-to-culture conversion in liquid culture was observed as a nonsignificant trend.

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