The Natural Stilbenoid (-)-Hopeaphenol Inhibits HIV Transcription by Targeting Both PKC and NF-κB Signaling and Cyclin-Dependent Kinase 9.

While gene expression involved in PKCθ and NF-κB signaling was reduced by hopeaphenol plus PMA relative to cells treated with only PMA, these changes did not reach statistical significance (FDR > 5%), suggesting that this pathway may not be fully inhibited by hopeaphenol.

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