Early life adversity impaired dorsal striatal synaptic transmission and behavioral adaptability to appropriate action selection in a sex-dependent manner.

Front Synaptic Neurosci · 2023 · PMC10116150 · PMID 37091877

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0.0570

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showed a trendp = 0.057so close (0.05 < p ≤ 0.1)

Fragmented maternal care early in life differentially affected synaptic transmission in a sex-dependent manner In the DMS, AMPA/NMDA ratio showed a trend towards significant LBN condition × sex interaction (2-way ANOVA: F (1,57) = 3.776, p = 0.057) and a significant main effect of sex (2-way ANOVA: F (1,57) = 15.003, p < 0.001; Supplementary Figure 1A ).

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