The small molecule inhibitor BX-795 uncouples IL-2 production from inhibition of Th2 inflammation and induces CD4⁺ T cells resembling iTreg.

In accordance with the increased IL-2 protein levels observed after 24 hours of stimulation, Jurkat E6-1 cells stimulated with CD3/CD28 beads for 6 hours, highly significantly increased IL-2 ( Figure 1B ) but not IFN-γ ( Figure 1C ) mRNA levels with a clear trend towards increased IL-2 mRNA already at 0.24 μM of BX-795.

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