Effects of chronotype on antidepressant treatment and symptoms in patients with depression: a multicenter, parallel, controlled study.

Consistently, in this study, patients with different types of depression showed a trend of increasing remission rates at each point of visit during the study (p < 0.01), however, there was no significant difference among the three types of chronotypes at each visit point ( p > 0.05), which suggested that different chronotypes had no significant effect on the remission rate of depressive symptoms.

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The MEQ scores of the early-type group showed a decreasing trend, while the MEQ scores of the middle-type group increased relatively slowly, while the late-type group showed a significant increase (Fig. 1 ).

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