ESCRT recruitment to SARS-CoV-2 spike induces virus-like particles that improve mRNA vaccines.

Cell · 2023 · PMC10121106 · PMID 37146611

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failed to reach statistical significanceno p-value reported

Against Omicron BA.2, mean neutralization titers measured for mice that received S-EABR mRNA-LNP were also 10.9- and 8.2-fold higher compared with S mRNA-LNP and 7- and 12.2-fold higher compared with purified S-EABR eVLPs on days 56 and 112, respectively, but these differences narrowly failed to reach statistical significance ( Figures 4 D and 4G).

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