Reserpine maintains photoreceptor survival in retinal ciliopathy by resolving proteostasis imbalance and ciliogenesis defects.

Although statistically non-significant, chloroquine-treated organoids also showed a positive trend in rhodopsin expression ( Figure 5—figure supplement 1D ), providing further evidence in support of the autophagy pathway as a target for designing therapies.

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Although statistically non-significant, the level of autophagosome showed a decreasing trend in organoids treated with reserpine ( Figure 5—figure supplement 3A, B ).

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Reserpine-treated rd16 mice showed a trend of increase in scotopic a-wave and a significant increase in scotopic b-wave ( Figure 6C and D ), suggesting functional recovery of rod photoreceptors upon reserpine treatment.

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