Sleeping Beauty transposon system for GDNF overexpression of entrapped stem cells in fibrin hydrogel in a rat model of Parkinson's disease.

Drug Deliv Transl Res · 2023 · PMC10125957 · PMID 36853436

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showed a trendno p-value reported

5 A–D) showed a trend toward higher levels in the hydrogel-entrapped GDNF-adMSC group at 1 week and 1 month after transplantation surgery compared to the other groups at the same timepoint, but the differences were not significant between groups or over time.

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a nonsignificant trendno p-value reported

Treatment of GDNF-adMSCs without hydrogel showed a nonsignificant trend toward healthy control TH + ratio (median: 1.47, IQR: 0.95 to 1.72), and similar to the entrapment GDNF-adMSC group, a trend of an increased amount of TH + fibers was observed compared to diseased control after 1 month (Fig. 6 A).

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