Fetal Loss in Pregnant Rabbits Infected with Genotype 3 Hepatitis E Virus Is Associated with Altered Inflammatory Responses, Enhanced Virus Replication, and Extrahepatic Virus Dissemination with Positive Correlations with Increased Estradiol Level.

In HEV-P rabbits, viral loads in liver had a near-significant positive correlation with those in bile ( r = 0.70, P = 0.0510) ( Fig. 4E ) and significant positive correlations with those in feces at 28 dpi ( r = 0.91, P = 0.0018) and LIC ( r = 0.91, P = 0.0019) ( Fig. 4F and G , respectively).

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