Serum short chain fatty acids mediate hippocampal BDNF and correlate with decreasing neuroinflammation following high pectin fiber diet in mice.

Front Neurosci · 2023 · PMC10130583 · PMID 37123365

Europe PMC DOI

hedged sentences

0.0400

closest p · 0.8× alpha

0.0900

boldest claim

The sentences

marginally significantp = 0.04actually significant

Moreover, there was a marginally significant negative correlation observed between serum levels of butyric acid and IL-6 in the hippocampus, r = −0.38, t (27) = −2.14, p = 0.04.

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did not reach statistical significancep = 0.082so close (0.05 < p ≤ 0.1)

The addition of an interaction term to the model had only a marginal improvement in model parameters that did not reach statistical significance ( p = 0.082).

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a trend toward significancep = 0.09so close (0.05 < p ≤ 0.1)

Similar diet-induced reductions in hippocampal cytokines were observed in both sexes for IL-6, t (26) = −2.58, p = 0.016 and TNFα, t (26) = −3.11, p = 0.0045, and a trend toward significance in IL-1β t (26) = −1.73, p = 0.09 ( Figure 2B ).

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