Brain-Penetrating and Disease Site-Targeting Manganese Dioxide-Polymer-Lipid Hybrid Nanoparticles Remodel Microenvironment of Alzheimer's Disease by Regulating Multiple Pathological Pathways.

However, the effects of Ab‐TP‐MDNPs treatment, though showed a positive trend toward improvement in this population, was less significant than that at moderate AD stages, which further confirmed the importance of treating AD before reaching the advanced stage. 2.6.

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In advanced AD mice (9‐mo), Ab‐TP‐MDNPs treatment showed a trend toward reducing both types of A β plaques, however the differences observed were statistically insignificant (Figure S4B , Supporting Information).

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The level of HIF‐1 α , a biomarker of hypoxia, showed a decreasing trend in brain following Ab‐TP‐MDNPs treatment with statistical insignificance (Figure S3A , Supporting Information).

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