Multimodal immunogenomic biomarker analysis of tumors from pediatric patients enrolled to a phase 1-2 study of single-agent atezolizumab.

Nat Cancer · 2023 · PMC10132976 · PMID 37038005

Europe PMC DOI

hedged sentences

0.0500

closest p · 1.0× alpha

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boldest claim

The sentences

a statistical trendP = 0.05actually significant

We observed a statistical trend toward higher TMB in metastatic versus primary samples (medians 4.4 and 2.6 mut per Mb, respectively, t -test, P = 0.05).

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showed a trendP = 0.08so close (0.05 < p ≤ 0.1)

From a univariate analysis, patients whose samples had a TCRβ diversity score at or above the upper quartile (≥80.3) showed a trend toward longer PFS compared to patients whose samples harbored interquartile and first quartile levels of TCRβ diversity (log-rank test, P = 0.08; Fig. 4b ).

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