High glucose-induced STING activation inhibits diabetic wound healing through promoting M1 polarization of macrophages.

Lastly, the most crucial point was that when we finally used STING gene-edited BMDM to subcutaneously injection in the wound, although BMDM could be effectively delivered to the local wound tissue, the expression of STING expression and its downstream pro-inflammatory signaling in wound tissue showed a trend consistent with the polarization function of macrophages.

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We also observed that STING signaling and the phosphorylation status of IRF3 and NF-κB showed an increasing trend consistent with the increased pro-inflammatory state of the wound, increased macrophages infiltration, and refractory wound healing.

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