Heterogeneity of asthma-chronic obstructive pulmonary disease (COPD) overlap from a cohort of patients with severe asthma and COPD.

Compared with patients with pure severe asthma, the risk for exacerbation had a tendency to be higher in ACO either from severe asthma or COPD cohort [adjusted odds ratio (aOR): 1.54, 95% confidence interval (CI): 0.22–10.95 or aOR: 2.15, 95% CI, 0.59–7.85], although the difference did not reach statistical significance.

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