The predictive and prognostic value of weight loss and body composition prior to and during immune checkpoint inhibition in recurrent or metastatic head and neck cancer patients.

Additionally, body weight loss >5% over the 6 months prior to ICI therapy showed a trend toward worse OS in Ueki et al.'s univariable analysis. 34 Patients presenting with cachexia at baseline but stable weight during ICI therapy, indicating an arrest in catabolism, showed significantly better survival outcomes.

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