Large multi-ethnic genetic analyses of amyloid imaging identify new genes for Alzheimer disease.

The signal in the CR1 locus, chr1q.32.2 (rs679515, P = 2.7 × 10 –08 , β = 0.15, SE = 0.03, MAF = 0.18) was in high LD (R 2 = 0.97) with previously observed signal in the NHW and multi-ethnic meta-analysis (chr1q.32.2), also remained significant in the APOE ɛ4+ strata, but only nominally significant in the APOE ɛ4- (P = 0.02, β = 0.05, SE = 0.02).

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We looked for SNPs in high LD with these signals and found several SNPs in high LD that were also highly significant, indicating them to be potential new signals and not an imputation error or artifact (Additional file 1 : Table S14).

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