Statistically significant DMRs can be found even in the absense of single genome-wide significant CpGs, as the aggregation of multiple, nominally significant, adjacent CpGs can together lead to a genome-wide significant DMR [ 48 ].
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Statistically significant DMRs can be found even in the absense of single genome-wide significant CpGs, as the aggregation of multiple, nominally significant, adjacent CpGs can together lead to a genome-wide significant DMR [ 48 ].