As indicated in Figure 2 A, C, D, LPS stimulation increased the protein levels of ARG1 and CD206, two markers of M2-type polarization [ 25 ], in WT Trem2 BV2 microglia, but these increments did not reach statistical significance ( p > 0.05).
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The <i>TREM2</i> H157Y Variant Influences Microglial Phagocytosis, Polarization, and Inflammatory Cytokine Release.
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