Proinflammatory microenvironment promotes lymphoma progression in mice with high megakaryocyte and TPO levels.

Furthermore, in support of a procoagulant state, we noted upregulated hallmark gene sets associated with coagulation close to significance in blood-residing Eμ- myc cells in Tpo Tg mice ( Figure 7 A).

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Spleen weight and lymphocyte counts tended to increase, albeit variably and did not reach statistical significance in Tpo Tg mice compared with the WT ( supplemental Figure 2 G,I).

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