Germline-targeting HIV-1 Env vaccination induces VRC01-class antibodies with rare insertions.

20 , 41 While not all observed frequencies are statistically significantly different, a clear trend is visible where GT1.2 (long) selects for contact mutations more consistently and at up to 1,000-fold higher median frequencies with the exception of Q61W that might rely on N276-glycan exposure ( Figure 3 G).

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