did not reach statistical significancep = 0.0588
The mean serum creatinine level for the 1KI group ( n = 10, mean = 0.3333 ± 0.0558) was 1.4-fold higher than that of the 2KNI group ( n = 14, mean = 0.2391 ± 0.052), 3-fold higher than that of the 1KNI group ( n = 9, mean = 0.1071 ± 0.050), and 1.8-fold higher than that of the 2KI group ( n = 10, mean = 0.1826 ± 0.0553) but this increase did not reach statistical significance ( p = 0.0588) ( Figure 3 C).