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Single injection of lidocaine to reduce tourniquet hypertension in ambulatory arthroscopic patients under general anaesthesia: randomized, double-blind, placebo-controlled clinical trial.

BJS Open · 2023 · PMC10144628 · PMID 37115653

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showed a trendno p-value reported
TNF-α showed a trend of a sharp increase and rapid decrease, and reached a peak within 3 h 39 , 40 .

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.