Similar to what was seen in the patients’ tumor data, we found that there was no significant correlation (r = −0.3086; p = 0.2448) between APC deficiency and increased MDR1 expression ( Figure 2 C), but there was a negative trend.
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APC Loss Prevents Doxorubicin-Induced Cell Death by Increasing Drug Efflux and a Chemoresistant Cell Population in Breast Cancer.
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