Targeting IRG1 reverses the immunosuppressive function of tumor-associated macrophages and enhances cancer immunotherapy.

Sci Adv · 2023 · PMC10146892 · PMID 37115931

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failed to reach statistical significanceno p-value reported

PD-1 blockade exhibited a tendency to further decrease KPC tumor growth in Irg1 −/− mice but failed to reach statistical significance, even with more proinflammatory TAMs and increased infiltration of CD8 + T cells (fig.

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