Furosemide exacerbated the impairment of renal function, oxygenation and medullary damage in a rat model of renal ischemia/reperfusion induced AKI.

VO 2 /TNa + ratio increased in the IR + F group at T2 compared to BL (1.9 ± 1.3 at BL vs 8.2 ± 10 at T2, p < 0.05), it was also higher in the IR + F group than in the C and C + F groups (2.5 ± 0.9 in the C and 2.8 ± 1.3 in C + F vs 8.2 ± 10 in IR + F group, p = 0.07), but this rise did not reach statistical significance in comparison to the IR group (3.3 ± 2 in IR vs 8.2 ± 10 in IR + F, p = 0.07) (Fig. 6 C).

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