Pro-inflammatory factors such as VCAM-1, TNF- α , IL-6 and CD68 showed a trend to increase but with no significant differences in the aortae of ApoE – / – EC- Metrnl – / – mice without atherosclerosis compared with their controls ( Fig. 8 B).
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Endothelial METRNL determines circulating METRNL level and maintains endothelial function against atherosclerosis.
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