Identification of immune-associated genes in diagnosing osteoarthritis with metabolic syndrome by integrated bioinformatics analysis and machine learning.

A search of the GEO database revealed that RNF170 protein expression was significantly increased in human monocytes after infection with human immunodeficiency virus (HIV) ( 61 ), and when the body’s fibroblasts underwent an immune response to cytomegalovirus infection, the expression level of RNF170 protein in fibroblasts showed a trend of first increasing and then decreasing ( 62 ), and in general, RNF170 is extremely important in natural immunity.

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