A pilot investigation of differential hydroxymethylation levels in patient-derived neural stem cells implicates altered cortical development in bipolar disorder.

This is a reflection of a significant skew in the 5hmC fold changes between iPSC and NSC cell lines ( Figure 2C ), with 53.8% of tested sites exhibiting negative FC (i.e., NSC hypo -hydroxymethylation), but increasing to 89.4% among nominally significant t-test results at p < 0.05 ( n = 3,837; none are epigenome-wide significant).

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