Atrophy signaling pathways in respiratory and limb muscles of guinea pigs exposed to chronic cigarette smoke: role of soluble guanylate cyclase stimulation.

In CS-exposed animals, long-term treatment with BAY 41–2272 resulted in a significant reduction in the gastrocnemius levels of the aforementioned proteolytic markers, concomitant with weight recovery, with increased cGMP bioavailability, and a decrease in apoptosis values, although the latter did not reach statistical significance.

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