Association Between Intravenous Thrombolysis and Clinical Outcomes Among Patients With Ischemic Stroke and Unsuccessful Mechanical Reperfusion.

41 In combination with MT, the MR CLEAN-NO IV (Endovascular Treatment for Acute Ischemic Stroke in the Netherlands) trial reported a strong trend toward lower rates of death in the IVT group, but none of the noninferiority trials found a significant treatment effect on mortality. 15 , 16 , 29 , 40 The reduction of death rates should be treated with caution until further evidence becomes available.

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