Gut microbiome dysbiosis across early Parkinson's disease, REM sleep behavior disorder and their first-degree relatives.

Nat Commun · 2023 · PMC10154387 · PMID 37130861

Europe PMC DOI

hedged sentences

0.0010

closest p · 0.0× alpha

0.0560

boldest claim

The sentences

an increasing trendP value <0.001actually significant

The prevalence of functional constipation showed an increasing trend from control, RBD-FDR, RBD to early PD patients (8.3 vs 9.4 vs 45.3 vs 69.4%, P value <0.001).

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near-significantP value = 0.056so close (0.05 < p ≤ 0.1)

Previous study showed that mucin-degraders (family Prevotellaceae) were enriched in patients with depression and anxiety 47 , and a further subgroup analysis of present study also supported a near-significant increase of Akkermansia in unaffected controls with antidepressant ( n = 5, P value = 0.056) when comparing to those without (Supplementary Fig. 9b ).

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