Proteome changes in a human retinal pigment epithelial cell line during oxidative stress and following antioxidant treatment.

Five glutathione-related proteins were detected in the proteome but were not significantly altered, although two, glutathione S-transferase mu 3 (GSTM3) and glutathione peroxidase 1 (GPX1), showed a trend toward a decrease in expression ( Table 1 ).

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Results were considered significant if the P-value was ≤0.05 (*) and highly significant is the P-value was ≤0.01 (**). 3 Results 3.1 Differentially Expressed proteins involved in the antioxidant response based on biological process gene ontology We selected three broad molecular function categories for glutathione-related proteins: 1. glutathione binding/transfer 2. peroxidases and su

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