Fungal infection and neurodevelopmental outcomes at 18-30 months in preterm infants.

There was a significant trend (Armitage trend test p < 0.01) of decreasing IFI incidence with increasing GA, falling from 4.6% at 22–23 weeks GA to 0.2% at 28 weeks GA ( Figure 3 ).

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( 23 ) reported a decreasing trend of IFI (from 8.2% to 2.3% for infants <750 g BW; from 2.4% to 1.1% for infants 750–999 g BW) associated with increased use of prophylactic fluconazole (from 0.3 to 11.0 per 1,000 patients for infants <750 g BW) in Pediatrix NICUs.

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( 5 ) also reported an increasing trend of neonatal fungal infections.

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