“a significant trend”

There was a significant trend for PD patients with CI to score lower in the domains of memory ( p = 0.00) and verbal fluency ( p = 0.04, shown in Table 5 ).

While the remaining 533 genes were induced in both cell lines, there was a significant trend toward RBM12-dependent hyperactivation ( p < 2.2 × 10 −16 by Wilcoxon signed rank test).

Furthermore, a significant trend toward worse survival was found in the high-risk group ( p = 1.495 × 10 − 7 ).

To assess this possibility, we compared delta divergence from the consensus between neighboring ERVs (|neighbor_1_div—neighbor_2_div|) in ERV hotspots to other regions of the genome and report a significant trend in the opposite direction (Mann Whitney U, P = 3.317e−06), suggesting that SD is not the primary contributing mechanism to ERV hotspot formation.

In Cox regression, patients with multihit abnormalities had a 2.89-fold increased risk of death compared with those with wild-type TP53 (95% CI, 1.88-4.43), and those with single-hit abnormalities had a 1.63-fold increased risk of death (95% CI, 0.91-2.91) compared with those with wild-type TP53 ( Figure 2 D), with a significant trend in the HR as the number of TP53 abnormalities increased (likelihood ratio test, P = 5.42 × 10 −5 ).

NAbs targeting the V3, CD4bs, and MPER demonstrated a significant trend in increasing order of median IC 50 s (p = 0.0001, 0.0135, and 0.0249, respectively) and decreasing order of median breadth (p = 0.0001, 0.0598, and 0.0098, respectively) over time.

The exposure rate of the study population varied from 23.6% to 28.0%, and there was a significant trend toward increased exposure rate over time ( p < 0.0001).

Again, females showed the worst results on the IES-R, with a significant trend across the scale’s severity levels (p<0.0001).

Remarkably, we found a significant trend of reduced N expression from BA.2 to XBB.1.5 in mice of all three age groups, including weanling mice (−R = 0.79, p < 0.0001), adult mice (−R = 0.73, p < 0.0001), and aged mice (−R = 0.73, p < 0.0001) ( Fig. 6 d).

This analysis revealed an over time decrease in the mean dissimilarity, which was significant between the day of discharge with the 2-month ( P < 0.001) and 4-month samples ( P < 0.0001), and a significant trend over time ( P < 0.0001).

3 D and E ), a significant trend of decrease was found (posttest for trend, κ ̄ , **** P < 0.0001; κ ̄ , *** P = 0.0005).

A significant trend toward a decrease in the number of skin lesions was observed (p<0.0001).

The serum IL1α levels were similar for both groups when the comparison was performed using a Tukey’s test ( p = 0.778); however, the linear test for trend indicated a significant trend ( p = 0.0001).

We observed a significant trend before 2014 (slope = 1.47% increase in attachment rate per year, p < 0.0001), which flattened after 2014 (slope = 0.13%, p = 0.16).

However, mixed effects modelling revealed a significant trend for increasing LG at each timepoint (R2=.2, p<0.0001, PMA fixed effect, random intercept per infant).

Comparison of the staining patterns among patients revealed a significant trend towards increased frequency of DFS pattern (ANA associated diseases 10.4%, JIA 21.7% and nonrheumatic conditions 34.8%, p < 0.0001) and decreased frequency of homogenous staining (ANA associated diseases 34.3%, JIA 26.7% and nonrheumatic conditions 8.9%, p < 0.0001) in nonrheumatic conditions.

We found two other traits that showed a significant trend across the bins by median age, namely previous smoking status (slope = 0.0011, P = 6.9 × 10 −4 ) and aspirin use (slope = 0.0015, P = 1.8 × 10 −4 ).

However, at postoperative day (POD) 1, there was a significant trend toward an increase of albumin, hemoglobin and calcium in the ERAS group compared with the control group ( p < 0.001), which continued at POD 3 ( p < 0.05).

Further, the number of sickle-shaped blood vessels was associated with distant metastasis and OS, with a significant trend toward a poor prognosis (metastasis P < 0.001, Cox; OS P < 0.001, Cox) observed for patients with more than 100 such vessels in large maximal tumor sections.

A significant trend in the implementation of the HBCR programs in two groups was shown using chi-square test and independent t -test and variance with repeated measurements ( p < .001).

Consistently, when RDW was assessed as quartiles, compared with the reference group (quartile 1, RDW ≤12.4%), the HRs of recurrence of ischemic stroke was 1.372 (95% CI=0.671–2.805, P=0.386) in quartile 2 (12.8%≥RDW>12.4%), 1.835 (95% CI=1.222–2.755, P=0.003) in quartile 3 (13.3%≥RDW>12.8%), and 1.732 (95% CI=1.114–2.561, P<0.001) in quartile 4 (RDW>13.3%), with a significant trend test (P<0.001) after adjusting for covariables.

Multivariate analysis demonstrated that there was a significant trend (p = 0.001) for children of patients over spouse in disclosure of "prognosis of disease".

Among the total population sample, there was a significant trend for an increase in NVT carriage over the survey years in the rural site (Chi squared test for trend p < 0.001) and but not in the urban site (Chi squared test for trend p = 0.36).

However, we observed a significant trend in increases in CTX and P1NP ( p < 0.001) over time in all 3 arms.

Follicular stimulating hormone levels showed a significant trend among all participants (V B : 12.51 ± 1.72, V 3 : 13.54 ± 1.41, and V 12 : 13.10 ± 1.67 IU/mL; p < 0.001).