Treatment of Caco-2 CaSR−GFP cells with Ca 2+ upregulated only COX-2 gene expression, which in HT29 CaSR−GFP cells affected only the expression of the CaSR itself (the observed upregulation of the CaSR in Caco-2 CaSR−GFP following Ca 2+ treatment Cells did not reach statistical significance with P ∼ 0.1).
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The calcium-sensing receptor modulates the prostaglandin E<sub>2</sub> pathway in intestinal inflammation.
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