Co-culture of PDAC cells and macrophages underlined the advantage of experiments that allow bidirectional intercellular communication, revealing broad reciprocal adaptions and strong regulation of intercellular signals upon co-culture, with an overall trend toward increased secretion of cytokines and chemokines in both cell types.
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Cell-selective proteomics segregates pancreatic cancer subtypes by extracellular proteins in tumors and circulation.
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The sentences
Although trends could also be observed upon co-culture with mesenchymal PDAC cells, effects were less pronounced and did not reach statistical significance.