A comparison of prophylactic antiemetic therapy with palonosetron and dexamethasone as single-agents or in combination in adult patients undergoing laparoscopic surgery: A randomized trial.

For prevention of postoperative and postdischarge nausea and vomiting in high-risk patients showed that complete response was not different between the treatment groups for any time intervals, however, the combination group showed a trend toward greater satisfaction, especially in the “nausea domain,” and the combination therapy of palonosetron plus dexamethasone did not reduce the incidence of PONV when compared with palonosetron alone.[ 26 ] Our results corroborate this finding.

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