Development of an objective method to quantify hippocampal dentation.

In the left TLE group, the AUC values from the contralateral hippocampi showed a positive trend ( p = .07) with verbal memory acquisition scores but was not statistically significant.

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the described method is able to demonstrate pathological differences in hippocampal morphology in a real‐world clinical MRI dataset; (4) the proposed AUC method is reproducible and repeatable with nearly perfect intra‐ and inter‐rater reliability; (5) the AUC values from the right hippocampi showed a trend towards significance ( p = .07) with verbal memory measure in the left TLE patients supporting the “functional reserve” hypothesis (Chelune, 1995 ) and possible reorganization of verbal memory function (Kilpattu Ramaniharan et al., 2022 ); and (6) lastly, the proposed super resolution based segmentation approach using freely available software is capable of demonstrating dentation in the super resolution space (0.25 mm 3 ) that is not visible in native resolution (1.0 mm 3 ) segmentations.

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es (3) the described method is able to demonstrate pathological differences in hippocampal morphology in a real‐world clinical MRI dataset; (4) the proposed AUC method is reproducible and repeatable with nearly perfect intra‐ and inter‐rater reliability; (5) the AUC values from the right hippocampi showed a trend towards significance ( p = .07) with verbal memory measure in the left TLE patients supporting the “functional reserve” hypothesis (Chelune, 1995 ) and possible reorganization of verbal memory function (Kilpattu Ramaniharan et al., 2022 ); and (6) lastly, the proposed super resolution based segmentation approach using freely available software is capable of demonstrating dentation in the super resolution space (0.25 mm 3 ) that is not visible in native resolution (1.0 mm 3 ) segmentations.

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