Age, dose, and binding to TfR on blood cells influence brain delivery of a TfR-transported antibody.

Fluids Barriers CNS · 2023 · PMC10173660 · PMID 37170266

Europe PMC DOI

hedged sentence

0.0700

closest p · 1.4× alpha

0.0700

boldest claim

The sentences

did not reach statistical significancep = 0.07so close (0.05 < p ≤ 0.1)

AUC plasma was significantly higher in the blood from young mice, compared with aged mice, at high dosing (p = 0.04), but did not reach statistical significance for the low dose (p = 0.07).

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