Greater increases in intratumoral apparent diffusion coefficients after chemoradiotherapy predict better overall survival of patients with cervical cancer.

In patients, who had adjuvant therapy (n = 5) the increase in ADC values between pre- and post-EBRT did not reach statistical significance using two of the measurement methods (L-ROI mean , P = 0.084; S-ROI min, P = 0.105), while in patients with no adjuvant therapy (n = 47) the increase was highly significant with all ROI measurement methods ( P = 0.001) ( Table 3 ).

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In patients, who had adjuvant therapy (n = 5) the increase in ADC values between pre- and post-EBRT did not reach statistical significance using two of the measurement methods (L-ROI mean , P = 0.084; S-ROI min, P = 0.105), while in patients with no adjuvant therapy (n = 47) the increase was highly significant with all ROI measurement methods ( P = 0.001) ( Table 3 ).

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Although the L-ROI measurements provided significant or almost significant results in some analyses, the S-ROI measurements provided significant results in a larger number of analyses. ∆ ADC between pretreatment and post-EBRT ADC measurements proved to be a significant prognostic predictor in OS and RFS calculations.

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