Although the mechanism of action of Pirfenidone is not known, we observed decreased CD206 expression when both RP-832c and Pirfenidone were administered as monotherapies, with a trend toward significance in the combined treatments.
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A Novel CD206 Targeting Peptide Inhibits Bleomycin-Induced Pulmonary Fibrosis in Mice.
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We further observed decreases in M1 macrophage markers CD86, IL-1β, and iNOS expression, although they did not reach statistical significance ( Figure 4 E).