NF-κB Signaling Modulates miR-452-5p and miR-335-5p Expression to Functionally Decrease Epithelial Ovarian Cancer Progression in Tumor-Initiating Cells.

A decreasing trend in the number of spheres was noted more in the OVCAR8 cells than the OV90 cells when miR-335-5p was mimicked compared to the negative control, although it did not reach statistical significance ( Figure 3 C,D).

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In OVCAR8 cells, we observed a significant decrease in sphere-formation ability when the miR-452-5p inhibitor was added to cells with RELB silenced; there was a trend toward decreased sphere-formation ability after adding the inhibitor to control or RELA -silenced cells, which did not reach statistical significance ( Figure 3 B).

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