A numerical trend could also be observed amongst lymphocytes cultured with unactivated HUVECs, though this difference was not statistically significant.
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Immunoengineered MXene nanosystem for mitigation of alloantigen presentation and prevention of transplant vasculopathy.
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When examined using immunohistochemistry, we observed a strong trend towards fewer cytotoxic CD8 + T-lymphocyte infiltration into the adventitia of Ti 3 C 2 T x MXene treated animals ( Supplementary Fig.
This included a highly significant increase in the expression of the cyclin-dependent kinase inhibitor p21 Cip1 , which plays a critical role in the inhibition of transplant-induced T-cell activation, cell-mediated rejection, and the development of allograft vasculopathy ( Supplementary Fig.