Interestingly, only addition of low-dose everolimus (mTORC1 inhibitor) to anti-PD-1 led to better bladder or cervical cancer control 124 , 125 , while addition of high-dose everolimus to anti-PD-1 showed a trend towards worse tumour control 124 .
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Immunosuppression for immune-related adverse events during checkpoint inhibition: an intricate balance.
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