weakly significantp = 0.066
4 , the addition of NSE to the model1 improved risk prediction of 1-year AIS outcomes, leading to a weakly significant increase in C-statistics but significant improvement in reclassification (Δ AUC = 0.049, p = 0.066; NRI = 39.45%, p = 0.028; IDI = 5.47%, p = 0.126).