Peripheral modulation of antidepressant targets MAO-B and GABAAR by harmol induces mitohormesis and delays aging in preclinical models.

But, when these two treatments were added together, they induced a synergistic, almost significant improvement in the spare respiratory capacity, recapitulating the effects elicited by harmol.

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In brain, 7 h after treatment with harmol we detected a tendency to increased levels of the mitophagy marker PINK1, although it did not reach statistical significance; while levels of the phosphorylation of the AMPK target ACC1 or the autophagy marker LC3-II/LC3-I were not affected by harmol treatment (Fig. 4c and S4c ).

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