The reverse transcriptase inhibitor 3TC protects against age-related cognitive dysfunction.

Finally, because peripheral inflammation has been linked to brain aging and inflammation (Corlier et al., 2018 ), we measured levels of TNF‐α, IL‐1β, IL‐6, and IFN‐ɣ in plasma from treated and control mice; again, we observed trends for differences in these cytokines with aging and 3TC, but these effects did not reach statistical significance (Supplementary Figure 3b ).

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