Consisting in promising in vitro results, we evaluated the effectiveness of LIPUS by measuring EVs concentration in acute and chronic models at I = 0, 150 and 375 mW/cm2, both 2 and 24 h after treatment, observing a positive trend can be seen when comparing mice treated at I = 0 mW/cm2.
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Regulatory network analysis revealed a highly significant network comprised of 17 miRNAs, which was further associated with regulatory control of 54 target genes involved in inflammation, cell survival, translation, and synaptic development.
ROR‐positive EVs were also detected in the plasma of breast cancer patients and increased levels of ROR‐positive EVs showed a trend for association with poorer patient survival.