Barely Significant
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Randomized clinical trial on the effect of intermittent vibrational force application during orthodontic treatment with aligners on RANKL and OPG concentrations in crevicular fluid.

Bioeng Transl Med · 2023 · PMC10189425 · PMID 37206229

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In 2018, Judex and Pongkitwitoon 13 also described a greater response at molecular and cellular levels after 3 days of vibration with Acceledent®, including a rise in RANKL concentrations, although these differences again failed to reach statistical significance.

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